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Named for Hattiesburg native Sarah Gillespie, the museum houses the most complete art collection produced by Mississippians in the 20th century. It features more than 450 works by Mississippi artists such as Walter Anderson, Kate Freeman Clark, William Hollingworth, Theora Hamblett, Karl Wolfe, Wyatt Waters and Ethel Wright Mohamed, among many others. These artists and others were not insulated from patterns developing internationally in modern art, as many traveled and studied abroad. However, their work reflects idiosyncratic regionalism. Works record both the media and subject matter that concern regional artists.